Botox (OnabotulinumtoxinA) for Treatment of Migraine Symptoms

Migraine is one of the most common types of headache, and it is the second most common cause of neurological disorders, with an annual prevalence of about 15% of the population.

In an article published in Pain Research and Management in 2022, a study was highlighted that aimed to evaluate the effect of BoNT-A (Botox) on the duration and intensity of migraine attacks. This study set out to assess the effect of Botox on the duration and intensity of migraine attacks. In addition, effective injection sites were explored.
The findings showed immense promise in that, when used in individuals with chronic migraine, Botox decreased the frequency of migraine attacks per month. In addition, it was seen to influence pain intensity and migraine related disabilities. Medication use was also reduced as were emergency room visits.


The fact that the Botox injections were well tolerated, and undoubtedly led to a better quality of life for the participants, makes this is very viable option in the treatment of migraine. The average total dose is approximately 150 units to cover the corrugator, procerus, frontalis, temporalis, occipitalis, cervical paraspinals, and trapezius. It often requires up to three treatments for the best efficacy in reducing the intensity and number of headaches.

In individuals who suffer from vestibular migraine (migraine with vertigo) treatment reduced the frequency of migraines and improved the debilitating effects of these incidents. In addition, use of Botox reduced the frequency of attacks per month among individuals with chronic refractory migraine (migraine that is seemingly resistant to treatment and can occur up to eight days a month).

In conclusion, use of Botox can be a cost-effective option for treatment of various types of migraine, including chronic, episodic, unilateral, and vestibular types. By reducing the frequency and decreasing the severity of pain, Botox is a very viable treatment option for those suffering from migraine headaches.

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